BioXCell BE0146 說明書

世界*實驗材料供應商 BioXCell 正式授權上海起發為其中國代理， BioXCell 在一直是行業的*,一直為廣大科研客戶提供zui為的產品和服務,上海起發一直秉承為中國科研客戶帶來的產品，的服務，簽約 BioXCell 就是為了給廣大科研客戶帶來更加完善的產品和服務,您的滿意將是我們zui大的收獲

BioXCell 中國代理, BioXCell 上海代理， BioXCell 北京代理，BioXCell 廣東代理， BioXCell 江蘇代理BioXCell 湖北代理,BioXCell 天津,BioXCell 黑龍江代理,BioXCell 內蒙古代理,BioXCell 吉林代理,BioXCell福建代理, BioXCell 江蘇代理, BioXCell 浙江代理, BioXCell 四川代理,

Bio X Cell是一家位于美國新罕*爾州West Lebanon的生產用于生物醫學研究的高品質、散裝（毫克至克級）單克隆抗體的生物技術公司，該公司專業供應高純度、低內毒素的抗體、重組蛋白、融合蛋白的高科技生物技術公司，供應規模可從毫克至克。因該公司具有超過15年的單克隆抗體和重組蛋白的定制生產經驗，其研發的抗體采用先進的細胞培養生物反應器技術從培養組織中提取，并通過親和層析純化，進而保證了其高純度（>95％），低內毒素（<2 EU /毫克）特性，并且不添加防腐劑或穩定劑，因而特別適合科研、制藥和診斷行業的臨床前研究。如客戶機研究人員使用本公司抗體（需在銷售后六個月內，并遵循本公司推薦的試劑儲存方式）不能得到可出版的效果，本公司承諾將全部更換產品。而該公司生產的重組蛋白采用的發酵和純化技術，確保得到高活性和高純度的重組蛋白，目前Bio X cell公司具有所有主要表達系統進行重組蛋白的表達，包括：CHO、NSO、293、昆蟲細胞、大腸桿菌和酵母表達系統，并且采用的發酵技術，如攪拌槽內發酵和Wavebag系統，生產能力范圍從5-500L。BioXCell還有相應的 FC-region，his標簽，flag標簽和GST親和標簽的重組蛋白的純化設備和純化經驗。。此外，BioXCell提供相應的發酵和純化定制服務，根據客戶要求提供單克隆抗體雜交瘤細胞以及來源于哺乳動物，昆蟲和微生物表達系統如CHO，293，桿狀病毒ES，酵母，大腸桿菌等重組蛋白的發酵和純化服務。

InVivoMAb anti-mouse PD-1 (CD279)

Clone     RMP1-14

Catalog #  BE0146

Category   InVivoMab Antibodies

The RMP1-14 monoclonal antibody reacts with mouse PD-1 (programmed death-1) also known as CD279. PD-1 is a 50-55 kDa cell surface receptor encoded by the Pdcd1 gene that belongs to the CD28 family of the Ig superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. PD-1 expression declines after successful elimination of antigen. Additionally, Pdcd1 mRNA is expressed in developing B lymphocytes during the pro-B-cell stage. PD-1’s structure includes a ITIM (immunoreceptor tyrosine-based inhibitory motif) suggesting that PD-1 negatively regulates TCR signals. PD-1 signals via binding its two ligands, PD-L1 and PD-L2 both members of the B7 family. Upon ligand binding, PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T-cell death. Additionally, PD-1 is known to play key roles in peripheral tolerance and prevention of autoimmune disease in mice as PD-1 knockout animals show dilated cardiomyopathy, splenomegaly, and loss of peripheral tolerance. Induced PD-L1 expression is common in many tumors including squamous cell carcinoma, colon adenocarcinoma, and breast adenocarcinoma. PD-L1 overexpression results in increased resistance of tumor cells to CD8 T cell mediated lysis. In mouse models of melanoma, tumor growth can be transiently arrested via treatment with antibodies which block the interaction between PD-L1 and its receptor PD-1. For these reasons anti-PD-1 mediated immunotherapies are currently being explored as cancer treatments. Like the J43 antibody the RMP1-14 antibody has been shown to block the binding of both mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1.

我們公司zui大優勢是強大的采購，

1：基本什么都能進口，血清，抗體，耗材，還有部分限制進口的，

2：貨品全，現經營過700多個品牌，基本所有生物試劑耗材都可以進口，特別是冷偏的產品那就更有優勢，

3：提供加急服務，一般1-2周到貨，超過時限加急費全免

4：價格公道，絕大部分價格有優勢，當然不能保證100%產品都是,因為意味著沒有服務.

5：良好的信譽，大部分客戶我們提供貨到付款服務，客戶包括清華，北大 交大 復旦，中山等100多所大學，ROCHE，阿斯利康，國藥 ，fisher等500多家公司

6：我們*代理的品牌有：Antibody Research Corporation，arcticzymes，Biorelevant，AmberGen, Inc. ，clemente-associates，clodronaiposomes，Columbia Biosciences，enzyme research，Gene Bridges GmbH，Genovis，AmberGen, Inc.  Biotechnology GmbH，Haematologic Technologies HTI Haemtech，hookelabs，Immudex，Innovative Research of America，inspiralis ，List Biological Laboratories, Inc.，lumafluor，Microsurfaces，multiplicom，nanotools，Pel-Freez Biologicals，pentapharm，progen，Protein Ark，QA-Bio,Inc，QA-Bio,IncQuickZyme Biosciences，Teknova，TriLink BioTechnologies, Inc.，Zyagen Laboratories 等

7：我們還是invitrogen,qiagen,Midland BioProducts Corporationam,sigma;neb,roche,merck, rnd,BD, GE,pierce,BioLegend等知名*批發，歡迎合作。