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          當(dāng)前位置:首頁(yè) > 技術(shù)文章 > listlabs 炭疽毒素說明書

          listlabs 炭疽毒素說明書

          更新時(shí)間:2018-12-10      點(diǎn)擊次數(shù):3226

          list biological laboratories公司是世界的科研毒素試劑供應(yīng)商,其毒素包括霍亂病毒,蛇毒,百日咳毒素等各類毒素,我公司常年低價(jià)供應(yīng),貨期快.有意者請(qǐng). 百日咳毒素長(zhǎng)期現(xiàn)貨供應(yīng),貨號(hào)181及180。

           

          listlabs 炭疽毒素說明書

          炭疽毒素Anthrax Toxins

           

          炭疽桿菌是炭疽病的病原體。炭疽桿菌產(chǎn)生的主要毒力因子是γ連接的聚-D-谷氨酸膠囊和由三種成分組成的外毒素,保護(hù)性抗原(PA),致死因子(LF)和水腫因子(EF)。這些蛋白質(zhì)不是單*毒的,而是以二元組合起作用。PA(細(xì)胞結(jié)合成分)與LF(酶部分之一)的復(fù)合物被稱為“致死毒素”并可導(dǎo)致死亡。PA和酶促EF一起引起皮膚水腫。分泌后,PA被膜肽酶切割,使63kDa羧基末端片段寡聚化成七聚體。切割是暴露EF和LF的結(jié)合位點(diǎn)的必要步驟。組裝的PA復(fù)合物和相關(guān)的LF或EF通過胞吞作用進(jìn)入細(xì)胞。PA介導(dǎo)LF和EF向細(xì)胞質(zhì)的轉(zhuǎn)移,其中這些酶識(shí)別并蛋白水解其靶標(biāo)。LF組分是一種鋅依賴性金屬蛋白酶,可裂解絲裂原活化蛋白激酶激酶(MAPKK),從而削弱其功能,從而阻斷MAPK信號(hào)通路。EF是鈣調(diào)蛋白依賴性腺苷酸環(huán)化酶,其在細(xì)胞中產(chǎn)生過量的環(huán)AMP,導(dǎo)致水腫。目前的研究集中于開發(fā)有效的疫苗以及篩選LF酶活性的有效抑制劑。

          含有炭疽LF切割位點(diǎn)的FRET肽底物可作為MAPKKide®獲得,并可用于評(píng)估LF的酶活性。

          炭疽毒素

          (炭疽水腫因子)

          水腫因子(EF)是鈣調(diào)蛋白依賴性腺苷酸環(huán)化酶,其可在易感細(xì)胞內(nèi)產(chǎn)生過量的腺苷酸環(huán)化酶。List Labs提供兩種形式的EF,它們都是在天然炭疽芽孢桿菌宿主中重組制備的。產(chǎn)物#178由天然序列組成,在N-末端具有另外的氨基酸組氨酸。產(chǎn)物#173的突變體EF S414N具有降低的腺苷酸環(huán)化酶活性,并且已顯示其充當(dāng)佐劑。

          炭疽毒素

          (炭疽水腫因子)

           

          炭疽水腫因子(EF),來自炭疽桿菌的
          重組體

          窗體頂端

          產(chǎn)品#和尺寸

          #178A(0.1毫克) - 160.00美元

           

           

           

          炭疽毒素

          (炭疽水腫因子)

           

          來自炭疽芽孢桿菌的炭疽水腫因子(EF),
          重組,突變體S447N

           

          產(chǎn)品#和尺寸

          #173B(0.5毫克) - 950.00美元

           

           

          貨號(hào)

          品名

           規(guī)格

          價(jià)格

          list104

          Cholera Toxin B Subunit (Choleragenoid) in low salt1

          0.5mg

          4930

          list106

          Cholera Toxin B Subunit Fluorescein Isothiocyanate Conjugate (BFITC)

          0.2mg

          9775

          list112

          Cholera Toxin B Subunit Biotin

          0.2mg

          9775

          list122

          Enterotoxin Type B from Staphylococcus aureus1,3

          0.5mg

          7225

          list123

          Enterotoxin Type B Toxoid from Staphylococcus aureus  1,3

          0.25mg

          8075

          list139

          Botulinum Neurotoxin Type B Toxoid

          10µg

          6800

          list150

          Diphtheria Toxin, unnicked from Corynebacterium diphtheriae

          1mg

          11050

          list151

          Diphtheria Toxoid, from Corynebacterium diphtheriae

          0.5mg

          10625

          list153

          Toxin A Toxoid from Clostridium difficile

          100µg

          11900

          list156

          Pasteurella Multocida Toxin

          50µg

          8075

          list160

          Exotoxin A from Pseudomonas aeruginosa

          1mg

          4420

          list161

          Shiga Toxin 1 from Escherichia coli1,4,8

          10µg

          11900

          list162

          Shiga Toxin 2 from Escherichia coli1,4,8

          10µg

          11050

          list174

          Anthrax Protective Antigen, Activated (PA 63) from Bacillus anthracis

          0.5mg

          9350

          list175

          Anthrax PA 63 - Fluorescein Isothiocyanate Conjugate (PAFITC)

          50µg

          7225

          list180

          Pertussis Toxin Islet-Activating Protein Lyophilized in buffer

          50µg

          5525

          list181

          Pertussis Toxin Islet Activating Protein Lyophilized (Salt-Free)

          50µg

          5525

          list184

          Pertussis Toxin Mutant

          50µg

          5525

          list186

          FIMBRIAE 2/3 from B. pertussis

          50µg

          5950

          list187

          Pertactin from Bordetella pertussus (69 kDa Protein)

          50µg

          4590

          list193

          Tetanus Toxin C Fragment

          10µg

          9350

          list201

          LPS from Escherichia coli O111:B4

          5mg

          3230

          list206

          LPS, Escherichia coli 0157:H7

          10.0mg

          4760

          list225

          LPS from Salmonella typhimurium

          5mg

          2890

          list301

          LPS from Escherichia coli J5 (Rc)

          5mg

          2890

          list302

          LPS from Escherichia coli K12, D31m4 (Re)

          5mg

          2890

          list304

          LPS from Salmonella minnesota R595 (Re)

          5mg

          2890

          list314

          LPS from Escherichia coli K12 strain LCD25

          1mg

          2890

          list400

          HPT™ LPS, highly purified from Bordetella Pertussis 165

          1mg

          5100

          list401

          Lipid A monophosphoryl from Salmonella minnesota R595

          1mg

          3400

          list421

          Ultra Pure LPS from Escherichia coli O111:B4

          1mg

          3570

          list423

          Ultra Pure LPS from Escherichia coli O55:B5

          1mg

          3570

          list433

          LISTÔ HPTÔ, LPS, highly purified Escherichia coli O113 LPS

          1mg

          4080

          list434

          Ultra Pure LPS from Salmonella minnesota R595 (Re)

          1mg

          3400

          list520

          SNAPtide® Peptide Substrate (o-Abz/Dnp)  (U.S. Patent #6,504,006)

          200nmoles

          9775

          list521

          SNAPtide® Peptide Substrate (FITC/DABCYL)  (U.S. Patent #6,504,006)

          200nmoles

          8500

          list523

          SNAPtideÒ Peptide Substrate flP6 (DABCYL/5-IAF), U.S. Patent Pending #61/252,675

          200nmoles

          8500

          list525

          Control Peptide for SNAPtideÒ #520

          200nmoles

          8500

          list526

          Control Peptide for SNAPtide® #521

          200nmoles

          8500

          list528

          Unquenched Calibration Peptide for SNAPtide®  521

          50nmoles

          2890

          list529

          Unquenched Calibration Peptide for SNAPtide®  520

          50nmoles

          2890

          list530

          MAPKKide® Peptide Substrate (o-Abz/Dnp)

          200nmoles

          5100

          list531

          MAPKKide® Peptide Substrate  (DABCYL/FITC)

          200nmoles

          5100

          list532

          MAPKKide® Plus (AMC) Specific Substrate for Anthrax Lethal Factor

          100nmoles

          4250

          list539

          Unquenched Calibration Peptide for MAPKKideÒ 530

          50nmoles

          2890

          list540

          VAMPtide® Peptide Substrate (o-Abz/Dnp)

          200nmoles

          8500

          list541

          VAMPtide® Peptide Substrate (FITC/DABCYL)

          200nmoles

          8500

          list542

          VAMPtide® Peptide Substrate (PL 150, Pya/Nop)

          200nmoles

          8500

          list549

          Calibration  Fluorophore for VAMPtideÒ 540

          100nmoles

          2890

          list550

          SNAP Etide® Peptide Substrate (o-Abz/Dnp)

          100nmoles

          6800

          list560

          SYNTAXtideÒ Peptide Substrate (o-Abz/Dnp) for C. botulinum Type C

          200nmoles

          8500

          list703

          Anti-Cholera Toxin B Subunit (Goat)

          0.1ml

          3060

          list752

          Anti-Toxin A from Clostridium difficile (Goat)

          0.5ml

          3230

          list760

          Anti-Exotoxin A (Goat)

          0.5ml

          3400

          list781

          Anti-Protective Antigen from Bacillus anthracis (Goat) affinity purified, Liquid6,7

          0.1mg

          7055

          list100B

          Cholera Toxin (Azide Free)1

          1mg

          3400

          list101B

          Cholera Toxin1

          1mg

          3400

          list101C

          Cholera Toxin1

          2mg

          5355

          list116L

          Alpha Toxin from C. septicum4,6,7

          50µg

          4930

          list126A

          Epsilon Toxin from C. perfringens1,4,8

          0.1mg

          5950

          list128A

          Botulinum Neurotoxin Type A Complex from Clostridium botulinum1,3

          10µg

          2890

          list128C

          Botulinum Neurotoxin Type A Complex from Clostridium botulinum1,3

          100µg

          5440

          list130A

          Botulinum Neurotoxin Type A from Clostridium botulinum1,3

          10µg

          5440

          list130B

          Botulinum Neurotoxin Type A from Clostridium botulinum1,3

          100µg

          13600

          list133L

          Botulinum Neurotoxin Type A Toxoid, Liquid6,7

          10µg

          5440

          list136A

          Botulinum Neurotoxin Type B. from Clostridium botulinum 1,3

          10µg

          5100

          list136B

          Botulinum Neurotoxin Type B, from Clostridium botulinum1,3

          100µg

          17000

          list138A

          Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum1,3

          10µg

          2890

          list138B

          Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum1,3

          100µg

          7225

          list140A

          Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum1,3

          10µg

          2890

          list140B

          Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum1,3

          100µg

          8925

          list141A

          Botulinum Neurotoxin Type E, Nicked, from Clostridium botulinum1,3

          10µg

          8075

          list146A

          Botulinum Neurotoxin Type D, Nicked, Recombinant from Clostridium botulinum1,3

          10µg

          5355

          list149A

          Diphtheria Toxin CRM Mutant

          0.25 mg

          8500

          list152C

          Toxin A from Clostridium difficile

          100µg

          9010

          list154A

          Toxin B Toxoid from Clostridium difficile

          20µg

          2890

          list15

          Toxin B  from Clostridium difficile

          2µg

          2890

          list155B

          Toxin B  from Clostridium difficile

          20µg

          8500

          list155C

          Toxin B  from Clostridium difficile

          200µg

          15300

          list155L

          Toxin B from Clostridium difficile, Liquid6,7

          50µg

          9860

          list157A

          Binary  Toxin from Clostridium difficile, A Subunit

          20µg

          5950

          list158A

          Binary  Toxin from Clostridium difficile, B Subunit

          40µg

          5950

          list159A

          Glutamate Dehydrogenase (GDH) from Clostridium difficile6,7

          0.1mg

          4930

          list169A

          Anthrax Lethal Factor (LF-A) , Recombinant from Bacillus anthracis Native Sequence

          0.1mg

          3060

          list169B

          Anthrax Lethal Factor (LF-A),Recombinant from Bacillus anthracis Native Sequence

          1mg

          12750

          list169L

           Anthrax Lethal Factor (LF-A),Recomb.from Bacillus anthracis 5,7

          0.2 mg

          5950

          list171E

          Anthrax Protective Antigen (PA), Recombinant from Bacillus anthracis

          0.5mg

          8755

          list172B

          Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis

          1mg

          12750

          list172C

          Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis

          10mg

          39525

          list172L

          Lethal Factor, Recomb from Bacillus anthracis, froz liq 5,7

          1.0 mg

          12750

          list173B

          Anthrax Edema Factor (EF), Recombinant Mutant S447N  from Bacillus anthracis

          0.5mg

          16150

          list176A

          Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis

          0.1mg

          5100

          list176B

          Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis

          1mg

          16150

          list177A

          Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis

          50µg

          5950

          list177B

          Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis

           0.25mg

          11050

          list178A

          Anthrax Edema Factor (EF), Recombinant from Bacillus anthracis

          0.1mg

          2890

          list179A

          Pertussis Toxin Islet Activating Protein (in glycerol)6,7

          50µg

          4845

          list188L

          Adenylate Cyclase Toxin from B. pertussis, Recombinant, Frozen Liquid5,7

          50µg

          5270

          list190A

          Tetanus Toxin2

          25µg

          2890

          list190B

          Tetanus Toxin2

          100µg

          9350

          list191A

          Tetanus Toxoid

          25µg

          4675

          list191B

          Tetanus Toxoid

          100µg

          13600

          list196A

          C-fragment, FITC Conjugate

          10µg

          6800

          list203A

          LPS, Escherichia coli O55:B5

          2.5 mg

          3060

          list500A

          SNAP-25 Recomb Protein Substrate for C. botulinum Type A and E Neurotoxin

          100µg

          5525

          list510A

          GST Synaptobrevin-2 Protein Recomb. Protein Substrate for C. botulinum Type B,D and F

          100µg

          5950

          list610A

          Botulinum Neurotoxin Type A Light Chain, Recombinant1

          10µg

          4760

          list611A

          Botulinum Neurotoxin Type A Light Chain, GST Fusion, Recombinant1

          15µg

          4760

          list612A

          Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain1

          50µg

          4760

          list613A

          Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain, GST Fusion1

          50µg

          4760

          list620A

          Botulinum Neurotoxin Type B Light Chain, Recombinant1

          10µg

          8500

          list622A

          Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain1

          50µg

          4760

          list623A

          Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain, GST Fusion1

          50µg

          4760

          list62

          Botulinum Neurotoxin Type C Light Chain, Recombinant1

          10µg

          8500

          list630A

          Botulinum Neurotoxin Type D Light Chain, Recombinant1

          10µg

          5695

          list650A

          Tetanus Toxin Light Chain, Recombinant

          10µg

          3825

          list690B

          Receptor for C. botulinum Type A Neurotoxin GST-SV2c luminal domain
          (U.S. Patent #8,476,024)

          100nmoles

          6800

          list730A

          Anti-Botulinum Neurotoxin, Type A (Chicken lgY), Liquid6,7

          0.1mg

          5610

          list731L

          Anti-Botulinum Neurotoxin, Type A (Mouse lgG monoclonal F1-40), Liquid6,7

          0.1mg

          5950

          list736A

          Anti-Botulinum Type B (Chicken lgY), Liquid6,7

          0.1mg

          5950

          list753A

          Anti-Clostridium difficile Toxin A (Chicken lgY), Liquid6,7

          0.1mg

          5780

          list754A

          Anti-Clostridium difficile Toxin B (Chicken lgY), Liquid6,7

          0.1mg

          5780

          list756A

          Anti-Clostridium difficile Glutamate Dehydrogenase, lgY, Liquid6,7

          0.1mg

          5780

          list757A

          Anti-Clostridium difficile Binary Toxin A subunit (Chicken lgY), Liquid6,7

          0.1mg

          5780

          list758A

          Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid6,7

          0.1mg

          5780

          list759A

          Biotinylated Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid6,7

          0.1mg

          5780

          list761L

          Anti-Shiga Toxin 1 (Rabbit), lgG, Liquid6,7

          0.5mg

          3400

          list765L

          Anti-Shiga Toxin 2 (Rabbit), IgG, Liquid6,7

          0.5mg

          2890

          list766L

          Anti-Shiga Toxin, Camelid Antibody, VHH, Liquid6,7

          0.5mg/ml

          5950

          list768L

          Biotinylated Anti-Lethal Factor from B. anthracis, IgY, Liquid6,7

          0.1mg

          5950

          list769B

          Anti-Lethal Factor from Bacillus anthracis (Chicken lgY), Liquid6,7

          0.2mg

          8500

          list771B

          Anti-Protective Antigen from Bacillus anthracis (Goat)

          1mg

          2890

          list772B

          Anti-Lethal Factor from Bacillus anthracis (Goat)

          1.0 mg

          2890

          list773L

          Anti-Edema Factor from Bacillus anthracis (Goat), Liquid6,7

          1mg

          2890

           

           

           

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